| 胰岛素抵抗大鼠模型的建立与评价 |
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| 引用本文： | 陈秋,夏永鹏,邱宗荫. 胰岛素抵抗大鼠模型的建立与评价[J]. 江苏医药, 2006, 32(3): 238-240 |
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| 作者姓名： | 陈秋 夏永鹏 邱宗荫 |
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| 作者单位： | 四川泸州医学院附属医院内分泌科;400016,重庆医科大学药学系 |
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| 基金项目： | 同济大学校科研和教改项目 |
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| 摘 要： | 目的探讨应用高胰岛素-正葡萄糖钳夹技术（钳夹法）对模型动物进行胰岛素敏感性评价的可行性。方法雄性Wistar大鼠喂以富含不饱和脂肪酸的特殊高脂肪膳食5周。应用钳夹法评价大鼠的胰岛素敏感性。结果与常规喂养大鼠相比，高脂膳食组的葡萄糖输注率显著降低，空腹血浆胰岛素显著升高。同时，高脂膳食大鼠出现高脂血症。结论应用钳夹法评价大鼠的胰岛素敏感性较为灵敏、准确、可靠。
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| 关 键 词： | 胰岛素抵抗 高胰岛素-正常血糖钳夹技术 |
| 收稿时间： | 2004-12-28 |
| 修稿时间： | 2004-12-28 |
Establishment and evaluation of rat models of insulin resistance |
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| CHEN Qiu,XIA Yongpeng,QIU Zongyin. Establishment and evaluation of rat models of insulin resistance[J]. Jiangsu Medical Journal, 2006, 32(3): 238-240 |
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| Authors: | CHEN Qiu XIA Yongpeng QIU Zongyin |
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| Affiliation: | Department of Pharmacology, Chongqing Medical University, Chongqing 400016, CHINA |
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| Abstract: | Objective To study the feasibility using euglycemic hyperinsulinemic clamp(EGHIC) technique.Methods Adult male Wistar rats were fed with high-fatty(59% of calories-fat) diet for 5 weeks.EGHIC technique was used to estimate their insulin sensitivity.Results Glucose(infusion) rates(GIR) in the rats with high-fat diet were lower than those in control rats.Meanwhile,(hyperinsulinemia) and hypertriglyceridemia were observed in the rats with high-fat diet.Conclusion EGHIC technique is sensitive,accurate and reliable in evaluating insulin sensibility in rats. |
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| Keywords: | Insulin resistance Euglycemic-hyperinsulinemic clamp technique |
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