磷酸钙骨水泥/氨磷汀/顺铂复合体理化特性及其修复骨缺损的实验研究

目的对磷酸钙骨水泥/氨磷汀/顺铂(CPC/amifostine/cisplatin)复合体用作肿瘤性骨缺损的填充材料进行可行性研究。方法按照质量比为1000:2:5的比例将磷酸钙骨水泥、顺铂、氨磷汀复合制备成人工骨复合体,对其进行固化时间、力学强度、孔隙率测定和扫描电镜、体外药物缓释、对骨肉瘤细胞的杀伤作用实验观察以及体内修复兔股骨骨缺损的实验研究。结果CPC/amifostine/cisplatin复合体在固化时间、力学强度、孔隙率方面同单纯磷酸钙复合体相比没有差别,具有可持续缓释药物的作用,且氨磷汀的加入不影响顺铂对骨肉瘤细胞的毒性作用,在兔体内可观察到材料本身的降解和新骨长入材料内部的病理学证据。结论CPC/amifostine/cisplatin复合体用作骨缺损的填充材料对于局部残存肿瘤细胞的消灭和缺损本身的修复是可行的。

Physicochemical and sustained drug release properities of calcium phosphate cement/amifostine/cisplatin complex and its effect in repairing bone defect due to tumor resection in rabbits

Objective To invistigate the feasibility of using calcium phosphate cement/amifostine complex as an new filling material for reparing bone defect caused by tumor resection. Methods Calcium phosphate cement (CPC)/cisplatin/amifostine complex was prepared at the mass ratio of 1000:2:5. The setting time, mechanical strength, and porosity of the complex were determined, and scanning electron microscopy and assessment of sustained drug release and inhibitory effect against osteosarcoma cells were carried out. Th...