丹参注射液对妊娠晚期羊水过少孕妇凝血功能的影响

目的探讨丹参注射液对晚期妊娠单纯羊水过少孕妇治疗前后羊水量和凝血功能的影响。方法选择妊娠晚期单纯羊水过少者47例，以丹参注射液30ml＋5％葡萄糖500ml，另加林格氏液1000ml＋VitC20静脉滴注，1次／d，连续治疗2周。治疗前后24h内测量羊水指数（AFI），抽取孕妇静脉血检测凝血功能，包括凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（Fbg）.结果治疗后患者AFI有显著提高，PT、APTT延长，Fbg下降，差异有显著统计学意义（均P〈0.01）。TT无影响，差异无统计学意义（P〉0．05）。结论丹参注射液可改善妊娠晚期凝血功能，降低血栓形成倾向，对治疗羊水过少有确切疗效。

Effect of Danshen injection on coagulation in late pregnant women with oligohydramnios

Objective To investigate the effect of Danshen （Radix Salviae Miltiorrhizae） injection on the amniotic fluid index and coagulation function in Jate pregnant women with oligohydramnios. Methods Forty-seven late pregnant women with o;igohydramnios were enrolled in this study. Intravenous drop of Danshen injection （30ml in 5%glucose 500ml plus Ringer＇s solution 1000ml＋Vitc 2.0g） was given q.d. for 2 weeks. The amniotic fluid index （AFI） was measured by ultrasonography; the coagulation function including prothrombin time （PT）, activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen （Fbg） were tested before and after treatment.Results After 2 weeks treatment AFI was significantly improved; the PT and APTT levels were increased and Fbg decreased （P〈0.01）; however the TT value was not changed （P 〉0.05）. Conclusion Danshen injection can improve the coagulation function in late pregnancy and reduce thrombosis tendency, so it is effective in treatment of oligohydramnios.