Studies on enzymatic dealkylation of D-lysergic acid diethylamide (LSD) |
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| Authors: | T Niwaguchi T Inoue Y Nakahara |
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| Affiliation: | First Chemistry Section. National Research Institute of Police Science, Tokyo, Japan |
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| Abstract: | New dealkylated metabolites, D-lysergic acid monoethylamide (LAE) and D-N?6-demethyl-lysergic acid diethylamide (norLSD), were formed by incubation of D-lysergic acid diethylamide (LSD) with rat liver 9000 g supernatant fractions. It was elucidated that these dealkylations were mediated by an NADPH and oxygen dependent enzyme in liver microsomes and were inhibited by SKF 525-A. Tranquillizing agents such as chlorpromazine, nitrazepam and meprobamatc, and certain brain monoamines inhibited these enzymatic dealkylations of LSD. Species differences were investigated. |
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