Purpura fulminans in a newborn infant with galactosemia |
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Authors: | Aysegul Zenciroglu Mehmet Sah Ipek Mustafa Aydin Abdurrahman Kara Nurullah Okumus Mustafa Kilic |
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Affiliation: | (1) Division of Neonatology, Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Hospital, Babur Street, No: 44, Altındag, 06080 Ankara, Turkey;(2) Division of Pediatric Hematology, Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Hospital, Ankara, Turkey;(3) Division of Nutrition and Metabolism, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey; |
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Abstract: | An 11-day-old neonate presented with purpura fulminans and was subsequently diagnosed with galactosemia. Neonatal purpura fulminans occurs predominantly in patients suffering from inherited protein C deficiency or disseminated intravascular coagulation associated with septicemia. Hemostatic changes in patients with liver disease may result in bleeding or, rarely, thrombosis. We suppose that in the present patient, deficiency of protein C, secondary to liver disease, was responsible for the development of purpura fulminans. Treatment consisted of blood and blood products and galactose-free formula. The patient recovered with residual mild psychomotor retardation and the lesions with minimal scarring. In conclusion, galactosemia also should be kept in mind as an uncommon cause of purpura fulminans in newborn infants. |
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