A Sib-Pair analysis of impulsivity in bipolar disorder type I |
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| Authors: | Karla Mathias de Almeida Fabiano Gonçalves Nery Ricardo Alberto Moreno Clarice Gorenstein Beny Lafer |
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| Institution: | 1. Bipolar Disorder Research Program (PROMAN), Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil;2. Mood Disorders Unit (GRUDA), Institute of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil;3. Laboratory for Medical Research 23 (LIM 23), Institute of Psychiatry, University of São Paulo School of Medicine;4. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil |
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| Abstract: | ObjectiveThe aim of this study was to compare impulsivity among patients with bipolar disorder, their siblings, and healthy controls in order to examine whether impulsivity in bipolar disorder is related to genetic liability for the illness.MethodsUsing the Barratt Impulsiveness Scale, we assessed 204 subjects: 67 euthymic outpatients with bipolar disorder type I, 67 siblings without bipolar disorder, and 70 healthy controls.ResultsImpulsivity scores were higher among patients with bipolar disorder than among healthy controls. Siblings showed higher motor impulsivity scores than did healthy controls.ConclusionsOur results suggest that motor impulsivity may be a vulnerability marker for bipolar disorder. Our data may contribute to further improve preventive strategies in subjects at high risk for bipolar disorder. |
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