结节性红斑与硬结性红斑皮损原位抗原研究

采用ＰＡＰ法对结节性红斑、慢性游走性结节性红斑、硬红斑及结节性血管炎４种疾病共３５例的原位抗原进行检测。结果在血管的检出例数分别为１１／１２，８／８，８／８，６／７；在胶原纤维表面的检出例数分别为１１／１２，７／８，８／８，６／７；所有病例表皮角朊细胞内均能检出；在血管腔内与血管腔外的红细胞表面的检出例数除慢性游走性结节性红斑为５／８外，其余病种均能检出。提示结节性红斑等４种疾病均为存在免疫复合物

Study of in situ antigen in lesions of erythema nodosum and erythema induratum

In situ antigens were detected with PAP method in skin biopises from 35 patients with erythema nodosum. chronic migrant erythema nodosum, erythema indura tum and nodular vasculitis. The results showed that the positive cases in the vessels of skin biopsies from the 4 kinds of disease were 11/12. 8 /8. 8 /8. 6/7 respectively: the positive cases on the surface of collagen fibers were 11/12- 7/8. 8 /8, 6/7. respee tively; All ('ases were positive in the keratinocytes of epidermis and the intra - luminal and extra-luminal erythrocytes surface of all cases were detected except that the positive cases from chronic migrant erythema nodosum were 5/8. These results suggest that all the four diseases are immune complex deseases, which have common immunopathologic basics. The results also reveal that immune complexes are in the process of dynamic elimination. Partial immune complexes may be excreted through epidermis by the mode of transepithelial elimination except that immune complexes are degraded through ery throcytes transportation.