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Port-wine stains: a new hypothesis
Authors:S Rosen  B R Smoller
Affiliation:1. Sección Reumatología, Hospital General Universitario de Alicante-ISABIAL, Alicante, España;2. Servicio Reumatología, Hospital Universitario Torrevieja, España;3. Servicio Nefrología, Hospital General Universitario de Alicante, España;4. Departamento de Medicina Clínica, Universidad Miguel Hernández, Elche, España;1. Great Ormond St Hospital for Children NHS Foundation Trust, and UCL GOS Institute of Child Health, London, United Kingdom;2. Mosaicism and Precision Medicine Laboratory, The Francis Crick Institute, London, United Kingdom;3. Dermatology, Hospital del Niño Jesús, San Miguel de Tucumán, Argentina;4. Dermatology, Puerta del Mar University Hospital, Cádiz, Spain;5. Manchester Centre for Genomic Medicine, Division of Evolution & Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom;6. Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University, NHS Foundation Trust, Health Innovation Manchester, Manchester, United Kingdom;7. Campus Kiel, Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany;8. Department of Neurosurgery, Great Ormond St Hospital for Children, NHS Foundation Trust, London, United Kingdom;9. Dermatology, Hospital del Niño Jesús, Madrid, Spain;10. Pediatric Neurology, Great Ormond St Hospital for Children, NHS Foundation Trust, London, United Kingdom;1. Maine Medical Center Research Institute, Scarborough, ME, United States;2. Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, United States;3. The Jackson Laboratory, Bar Harbor, ME, United States;4. Champions Oncology, Baltimore, MD, United States;5. Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK;1. Department of Surgery, Beckman Laser Institute and Medical Clinic, University of California–Irvine, Irvine, California;2. Department of Biomedical Engineering, University of California–Irvine, Irvine, California;3. Department of Dermatology, Brigham and Women''s Hospital, Harvard Institute of Medicine, Boston, Massachusetts;4. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi''an, Shaanxi, China;5. Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Abstract:Port-wine stains have been shown to be derived from a progressive ectasia of the superficial vascular plexus. Recent studies have documented a marked decrease in nerves associated with these abnormal vessels. It is suggested that this nerve loss is primarily of autonomic origin (sympathetic) and the failure to regulate blood flow is the basis for the progressive vascular ectasia that characterizes these lesions.
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