| Abstract: | Mice were immunized with an allogeneic tumour antigen using various adjuvants and were subsequently challenged with live tumour cells. Immunization using certain adjuvants led to accelerated destruction of the subsequent tumour allograft, whilst the use of Freund's complete and incomplete adjuvant (CFA and IFA) led to enhanced tumour growth and eventual death of the mice. Pretreatment with Freund's complete adjuvant without antigen also resulted in enhanced tumour growth. Enhancing antibody was not detected in the sera or on the tumour cells, though some of the sera were able to inhibit cell-mediated cytotolysis of tumour cells. The mice pretreated with CFA, with or without antigen, showed a depressed cell-mediated cytotoxicity against tumour cells when compared with untreated mice. |
