| 皮下埋植吡喹酮缓释剂控制家犬细粒棘球绦虫感染的实验研究 |
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| 引用本文： | 焦伟,柴君杰,吴树春,伊斯拉音·乌斯曼,王鸣杰,尤纪青,付承,瞿群,张文林.皮下埋植吡喹酮缓释剂控制家犬细粒棘球绦虫感染的实验研究[J].中国人兽共患病杂志,1999,9(3):51-53. |
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| 作者姓名： | 焦伟 柴君杰 吴树春 伊斯拉音·乌斯曼 王鸣杰 尤纪青 付承 瞿群 张文林 |
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| 作者单位： | [1]新疆地方病防治研究所 [2]中国预防医学科学院寄生虫病研究所 |
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| 基金项目： | 国家“九五”科技攻关项目!96－906－04－09 |
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| 摘 要： | 家犬皮下埋植吡喹酮缓释剂的剂量与驱虫效果相关。用50mg／kg剂量在埋植后4个月以细粒棘粒蚴原头节进行攻击可保护家犬不受感染。3只家犬埋植剂量为36．36、4444和66．66mg／kg吡喹酮，3个月药物释放率各为76.7％、65.8％和56．1％。血液吡喹酮浓度在埋植后10天至3个月维持在0．8974～3．6849μg／ml之间。50mg／kg吡喹酮剂量对植药犬的肝肾功能无明显影响。
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| 关 键 词： | 吡喹酮 缓释剂 细粒棘球绦虫 |
EXPERIMENTAL INVESTIGATION ON THE CONTROL OF ECHINOCOCCUS GRANULOSUS INFECTION IN DOGS BY SUBCUTANEOUSLY PLANTATION WITH A SLOW RELEASED PREPARATION OF PRAZIQUANTEL |
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| Jiao Wei,Chai Junjie,Wu Shuchun,Israyil.Osman,Wang Minjie,You Jiqing,Fu Chen,Qu Qun,Zhang Wenlin.EXPERIMENTAL INVESTIGATION ON THE CONTROL OF ECHINOCOCCUS GRANULOSUS INFECTION IN DOGS BY SUBCUTANEOUSLY PLANTATION WITH A SLOW RELEASED PREPARATION OF PRAZIQUANTEL[J].Chinese Journal of Zoonoses,1999,9(3):51-53. |
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| Authors: | Jiao Wei Chai Junjie Wu Shuchun IsrayilOsman Wang Minjie You Jiqing Fu Chen Qu Qun Zhang Wenlin |
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| Abstract: | The dehelminthic efficacy of the slow released preparation subcutaneously planted in dogs correlated withdoses of praziquantel. With the dose of 5Omg/kg of praziquantel may prevent the dogs from challenging infection with proto-scolices of E. granulosus. Three dogs planted with 36. 36mg/kg, 44. 44mg/kg and 66. 66mg/kg of praziquantel the drug releaserate were 76' 7%, 65. 8% and 56. l % respectively in 3 months and the concentration of praziquatel in serum of these dogswere sustained within O. 8974~3. 6849 pg/ml. By examination the functions of the liver and kidney have not resulted any ab-normalities in the dogs of drug plantd. |
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| Keywords: | Praziquatel Slow released preparation Echinococcus granulosus |
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