| 巴戟素对急性缺血性脑损伤保护作用的机制研究 |
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| 引用本文： | 陈朝凤,谭宝璇,陈洁文,李小英,林锐珊,林励.巴戟素对急性缺血性脑损伤保护作用的机制研究[J].广州中医药大学学报,2000,17(3):215-217. |
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| 作者姓名： | 陈朝凤 谭宝璇 陈洁文 李小英 林锐珊 林励 |
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| 作者单位： | 广州中医药大学,广州,510405 |
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| 基金项目： | 国家中医药管理局资助项目(NO.97L025) |
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| 摘 要： | 巴戟素是从中药巴戟天中提取的一种糖甙类单体物。本实验采用生化检测和放射性核素示踪法，探讨巴戟素对缺血／缺氧性脑损伤保护作用的机制。结果显示：巴戟素可提高急性脑缺血衰老大鼠脑组织超氧化物歧化酶（ＳＯＤ）和谷胱甘肽过氧化酶（ＧＳＨ－Ｐｘ）活性（Ｐ〈０．０１），减少过氧化脂质（ＬＰＯ）含量（Ｐ〈０．０５）；能增加老龄小鼠脑组织葡萄糖含量（Ｐ〈０．０３）；但对急性脑缺血衰老大鼠脑组织一氧化氮（ＮＯ）含量无
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| 关 键 词： | 巴戟素 药理学 急性缺血性脑损伤 保护作用 |
| 修稿时间： | 1999-12-08 |
Mechanism of Bajisin's Protective Effect on Acute Cerebral Ischemic Injury |
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| CHEN Zhaofeng,TAN Baoxuan,CHEN Jiewen,LI Xiaoying,LIN Ruishan,LIN Li.Mechanism of Bajisin's Protective Effect on Acute Cerebral Ischemic Injury[J].Journal of Guangzhou University of Traditional Chinese Medicine,2000,17(3):215-217. |
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| Authors: | CHEN Zhaofeng TAN Baoxuan CHEN Jiewen LI Xiaoying LIN Ruishan LIN Li |
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| Abstract: | Bajisin is a kind of glucocide monomer extracted from Radix Morindae Officinalis. Biochemical test and radionuclide tracer methods were used to study the mechanism of Bajisin's protective effect on acute cerebral ischemic injury. The results showed that Bajisin increased the activity of superoxide dismutase and glutathione peroxidase(P< 0.01 ), reduced the content of lipid peroxide (P< 0.05 ) and raised the glucose content in the brain tissue of senile mice with acute cerebral ischemia, but had no obvious influence on the NO content (P> 0.05 ). It is suggested that the mechanism of Bajisin's protective effect on acute cerebral ischemic injury is related to the counteraction of lipid peroxidation and the improvement of glucose metabolism in brain tissue. |
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| Keywords: | BAJISIN/pharmacology MORINDA OFFICINALIS/therapeutic use BRAIN INJURIES/TCD therapy BRAIN CHEMISTRY SUPEROXIDE DISMUTASE/analysis LIPID PEROXIDES/analysis GLUTATHIONE PEROXIDASE/analysis |
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