High dose Allura Red,rather than the ADI dose,induces structural and behavioral changes in the medial prefrontal cortex of rats and taurine can protect it

Allura Red is a food color that can lead to neurotoxicity. Taurine is an organic compound that can act as a neuroprotectant. This study aimed to assess the effects of Allura Red with or without taurine consumption on rats’ medial Prefrontal Cortex (mPFC). The subjects were divided into six groups as follows: distilled water, taurine (200?mg/kg/day), and low (7?mg/kg/day?=?acceptable daily dose), and high (70?mg/kg/day) doses of Allura Red with or without taurine consumption for six weeks. The results of novel objects recognition and eight-arm radial maze tests indicated impairment of memory in the Allura Red groups. Subsequently, their brains were analyzed using stereological methods. Both doses of Allura Red caused an increase in working and reference memory errors during the acquisition and retention phases in comparison to the distilled water group (p?