代谢综合征患者胰岛素抵抗与代谢紊乱的关系

目的　探讨代谢综合征 (MS)患者胰岛素抵抗 (IR)与代谢紊乱的关系。方法　 6 7例MS患者 ,测量其身高、体重、腰围、臀围、空腹血糖 (FBG)、血清胰岛素 (FINs)、血脂、纤维蛋白原 (Fg)、纤溶酶原激活物抑制物 1(PAI 1)、尿微量白蛋白 (MAU)。并根据胰岛素抵抗度分为A组 (<2 .5 )、B组 (>2 .5 )。结果　两组患者的体重指数 (P <0 .0 5 )、Fg(P <0 .0 5 )、甘油三酯 (P <0 .0 1)、FBG(P <0 .0 1)、PAI 1(P <0 .0 1)、FINs(P <0 .0 1)间差别有统计学意义 ;相关分析显示IR与甘油三酯、FBG、FINs、PAI 1、MAU、体重指数等呈正相关 ,与高密度脂蛋白呈负相关。结论　MS患者胰岛素抵抗与肥胖、脂代谢紊乱、凝血系统和纤溶系统等代谢紊乱密切相关

Relationship between insulin resistance and metabolism disorder in the metabolism syndrome

Objective To study the relationship between the insulin resistance and metabolism disorder in metabolism syndrome.Methods we selected 67 patients with the metabolism syndrome. Anthropometric measures,fasting plasma glucose, insulin levels, lipid profiles, plasminogen activator inhibitor-1,fibrinogen and microalbuminuria were measured. Insulin resistance was estimated by the homeostasis model assessment(HOMA-IR). The subjects were divided into two groups according to the value of HOMA-IR. Values> 2.5 and values< 2.5 were indicative of the insulin resistant state.Results There were significant difference in the levels of BMI( P < 0.05),Fg( P < 0.05),TG( P < 0.01),FBG( P < 0.01),PAI-1( P < 0.01),FINs( P < 0.01) between two groups. IR was positively correlated with TG,FBG,FINs,PAI-1,BMI and negatively correlated with HDL. Conclusion Insulin resistance might be an important factor responsible for the metabolic disorder of lipid profiles,PAI-1and Fg in the metabolism syndrome.