| Effective induction of immune tolerance by portal venous infusion with IL-IO gene-modified immature dendritic cells leading to prolongation of allograft survival |
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| 引用本文： | ZhangM WangQ LiuY SunY, DingG FuZ MinZ ZhuY CaoX. Effective induction of immune tolerance by portal venous infusion with IL-IO gene-modified immature dendritic cells leading to prolongation of allograft survival[J]. 第二军医大学学报, 2005, 26(5): 470-470 |
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| 作者姓名： | ZhangM WangQ LiuY SunY DingG FuZ MinZ ZhuY CaoX |
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| 作者单位： | InstituteofImmunologyandTransplantationCenter,SecondMilitaryMedicalUniversity,Shanghai200433,China |
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| 摘 要： | Dendritic cells (DC) not only initiate T cell responses, but are also involved in the induction of tolerance. The functional properties of DC are strictly dependent on their state of maturation. It has been shown that immature DC can induce immune tolerance and prolong allograft survival. Interleukin-10 (IL-10) is an important immunosuppressive eytokine which inhibits maturation and function of DC. In order to improve the tolerogenieity of DC, we and others showed that adenovirus vectors can effectively mediate IL 10 genetic modification of DC, and IL-10 genetic modification can inhibit MHC Ⅱ, B7.2,
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Effective induction of immune tolerance by portal venous infusion with IL-10 gene-modified immature dendritic cells leading to prolongation of allograft survival |
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| Zhang M,WANG Q,liu Y,Sun Y,Ding G. Effective induction of immune tolerance by portal venous infusion with IL-10 gene-modified immature dendritic cells leading to prolongation of allograft survival[J]. Former Academic Journal of Second Military Medical University, 2005, 26(5): 470-470 |
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| Authors: | Zhang M WANG Q liu Y Sun Y Ding G |
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| Affiliation: | Zhang M；WANG Q；liu Y；Sun Y；Ding G |
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