银屑病患者皮损中VEGF受体FLT-1和KDR的表达

目的:检测VEGF受体FLT-1与KDR在寻常型银屑病皮损中的表达水平,探讨其在银屑病发病中的意义。方法:应用免疫组化SABC法,检测37例寻常型银屑病患者皮损和37例正常人皮肤组织FLT-1蛋白、KDR蛋白的表达。结果:寻常型银屑病皮损处的FLT-1蛋白和KDR蛋白的表达水平明显强于正常对照组(P<0.001);KDR的表达强度与寻常型银屑病严重程度指数PASI评分有显著正相关(r=0.93,P<0.001),且KDR的表达强度高于FLT-1的表达强度(P<0.05)。结论:VEGF的两种受体FLT-1与KDR在银屑病新生血管形成中具有重要作用,其中KDR起主要作用。通过阻断VEGF受体KDR以抗血管生成,可望为治疗银屑病提供一种新的有效方法。

Expression of vascular endothelial growth factor receptors FLT-1 and KDR in patients with psoriasis vulgaris

Objective: To investigate the levels of vascular endothelial growth factor(VEGF) receptors(FLT-1 and KDR) of psoriatic lesions,and to explore its significance in the pathogenesis of psoriasis.Methods: The expression of FLT-1 and KDR in 37 patients with psoriasis vulgaris and 37 normal controls were measured by immunohistochemistry technique(SABC).Results: The expressions of FLT-1 and KDR in psoriatic lesions were remarkably higher than those in normal controls(P<0.001).The expression of KDR in psoriatic lesions was higher than that of FLT-1's(P<0.05),and the expression of KDR in psoriatic lesions was positively correlated to PASI(r=0.93,P<0.001).(Conclusion): VEGF receptors(FLT-1 and KDR) play an important role in the angiogenesis in psoriasis,of which KDR plays a more important role.Anti-angiogenesis by blocking the VEGF receptors may be an effective therapy in the treatment of psoriasis.