Early second-trimester plasma levels of NT-proBNP in women who subsequently develop early-onset preeclampsia |
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| Authors: | Katja Junus Anna-Karin Wikström Anders Larsson Matts Olovsson |
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| Institution: | 1. Department of Women’s and Children’s Health,;2. Department of Women’s and Children’s Health,;3. Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden and;4. Department of Medical Sciences, Biochemical Structure and Function, Uppsala University, Uppsala, Sweden |
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| Abstract: | Plasma levels of NT-proBNP are elevated in women with preeclampsia at the time of diagnosis. The objective of this case-control study was to evaluate N-terminal proBNP (NT-proBNP) in maternal plasma as an early second-trimester biomarker for prediction of early-onset preeclampsia. In early second-trimester samples, women who later developed preeclampsia at gestational age 34 wk?+?0 or earlier (n?=?16) had similar plasma levels of NT-proBNP (median 51.8, range 26.1–131.9?pg/ml) as women with uncomplicated pregnancy outcomes (n?=?43) (53.0, 14.9–184.2?pg/ml). The early second-trimester level of NT-proBNP cannot therefore be used as a predictive biomarker of early-onset preeclampsia. |
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| Keywords: | B-type natriuretic peptide biomarker BNP hypertension pregnancy |
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