Fetal anemia,cerebellar hemorrhage and hypoplasia associated with congenital Parvovirus infection |
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| Authors: | Laura Sanapo Michael Wien Matthew T Whitehead Anna Blask Michael Gallagher Roberta L DeBiasi |
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| Affiliation: | 1. Division of Fetal and Transitional Medicine,;2. Division of Radiology, Children's National Health System, Washington, DC, USA,;3. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The George Washington University School of Medicine and Health Science, Washington, DC, USA,;4. Division of Pediatric Infectious Diseases, Children's National Health System, Washington, DC, USA, and;5. Department of Pediatrics, Microbiology, Immunology and Tropical Medicine, The George Washington University School of Medicine and Health Science, Washington, DC, USA |
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| Abstract: | We report a case of fetal cerebellar hemorrhage and hypoplasia, identified by fetal MRI after intrauterine blood transfusion at 21 weeks’ gestation for treatment of severe anemia due to congenital Parvovirus infection. Postnatal MRI confirmed atrophy of bilateral cerebellar hemispheres and inferior vermis. Cerebellar capillaries may be extremely susceptible to hemodynamic changes in the setting of intrauterine blood transfusion due to severe anemia. Although the correlation between fetal intracranial anomalies and Parvovirus infection remains unclear, in this population, a detailed evaluation of the brain parenchyma should be considered prior to and after intrauterine blood transfusion. |
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| Keywords: | Congenital Parvovirus fetal anemia intrauterine transfusion cerebellar hemorrhage cerebellar hypoplasia |
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