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Cord blood erythropoietin and cord blood nucleated red blood cells for prediction of adverse neonatal outcome associated with maternal obesity in term pregnancy: prospective cohort study |
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| Authors: | Mahmoud H. Ibrahim Asmaa N. Moustafa Ahmed A. Fadil Saedii Ebtesam E. Hassan |
| Affiliation: | 1. Department of Obstetrics and Gynecology, Minia University Hospital, El-Minia, Egypt,;2. Department of Pediatrics, Minia University Hospital, El-Minia, Egypt,;3. Department of Clinical Pathology, Minia University Hospital, El-Minia, Egypt, and;4. Department of Public Health and Preventive Medicine, Minia University Hospital, El-Minia, Egypt |
| Abstract: | Objective: To determine the adverse pregnancy outcomes associated with maternal pre-pregnancy overweight and obesity and we measure cord blood erythropoietin and NRBC count as indices of hypoxia and predictors of neonatal outcome. Study design: This prospective cohort study was done in Minia University Hospital, carried out from May 2015 to April 2016. Two hundred and seventy full-term neonates born to mothers of various body mass indices were included. Excluded were neonates with major factors known to be associated with a potential increase in fetal erythropoiesis. Pre-pregnancy maternal BMI was calculated from maternally reported weight and height. Cord blood erythropoietin and nucleated red blood cells were measured. Results: There is a significant increase of various adverse pregnancy outcomes as cesarean section. Postpartum hemorrhage and macrosomia with the increase of maternal pre-pregnancy BMI. Significant positive correlations between cord blood erythropoietin and nucleated red blood cells with maternal BMI. Conclusion: The increase in the maternal pre-pregnancy BMI is associated with poor pregnancy outcomes. Cord blood erythropoietin and nucleated red blood cells can predict the poor neonatal outcome. |
| Keywords: | Maternal obesity nucleated red blood cells erythropoietin |