三合激素治疗53例外阴上皮内非瘤样病变的疗效分析

目的:探讨局部外用三合激素(雌激素、孕激素、雄激素)治疗外阴上皮内非瘤样病变的临床疗效.方法:对我科近5年来病理确诊的外阴上皮内非瘤样病变病人53例,随机分为2组,以局部外用三合激素加蜂蜜作为观察组(35例),以局部外用2%氢化可的松霜为对照组(18例),两组病例分别对症状、体征、皮肤弹性、颜色及病理检查等方面进行比较.结果:观察组治愈24例(67%),显效6例(17%),有效2例(5.7%),无效2例(5.7%),总有效率94.3%;对照组治愈0例(0%),显效5例(28%),有效8例(44%),无效5例(28%),总有效率72%.两组各指标比较P值均<0.01,有非常显著性统计学意义.结论:三合激素加蜂蜜是治疗外阴上皮内非瘤样病变一种疗效显著、使用简便的治疗方法.

Analysis of Curative Effect of Three-combined Hormones in Treatment of 53 Patient with Nonneoplastic Epithelial Disorders of Vulva

Objective: To discuss the curative effect of the exterior three-combined hormones (estrogen, pregnant and male hormone) in treatment of nonneoplastic epithelial disorders of vulva,and to find a treating method of significant effect and using conveniently.Method: Fivty three patients, with nonneoplastic epithelial disorders of vulva proved by pathology, were randomly divided into two groups. The observed group (35 cases) received the exterior three-combined hormones, the controlled group (18 cases) was given the exterior 2% cortisone ointment. The symptoms, signs, elasticity and colour of skin, and pathological test etc.in both groups were compared. Result: In the observed group, there were 24 cases had been cured (cured ratio was 67%), 6 cases had obvious effect (obvious effect ratio was 17%), and 2 cases had effect (effect ratio was 5.7%), and 2 cases without any effect after treatment(inefficiency was 28%). In the controlled group, none cases had been cured (cured ratio is 0%),5 cases had obvious effect (obvious effect ratio was 28%), and 8 cases had effect (effect ratio was 44%),and 5 cases without any effect after treatment (inefficiency was 28%). There was a very remarkable difference between the observed group and the compared group in therapy effect. Conclusion: Three-combined hormones therapy of nonneoplastic epithelial disorders of vulva is an effective, simple, and convenient treatment.