表皮生长因子受体、Her-2、血管内皮生长因子在子宫颈上皮内瘤变和鳞状细胞癌中的表达及意义

目的 探讨表皮生长因子受体（EGFR）、Her-2、血管内皮生长因子（VEGF）在子宫颈鳞状上皮内瘤变及子宫颈鳞状细胞癌组织中的表达,以及其在子宫颈鳞状细胞癌发生、发展及转移中的意义.方法 采用免疫组织化学法检测10例正常子宫颈组织、40例子宫颈鳞状上皮内瘤变、50例子宫颈鳞状细胞癌组织中EGFR、Her-2 、VEGF的表达情况.结果 EGFR、Her-2、VEGF在正常子宫颈组织中均无阳性表达,而在子宫颈上皮内瘤变中的阳性表达率分别为35.0％（14/40）、37.5％（15/40）、42.5％（17/40）,在鳞状细胞癌中的阳性表达率分别为70.0％（35/50）、78.0％（39/50）、76.0％（38/50）,差异有统计学意义（P＜ 0.01）;EGFR、Her-2、VEGF的表达与子宫颈鳞状细胞癌的组织学分级及淋巴结转移密切相关,而且Her-2、VEGF的表达与子宫颈鳞状细胞癌的临床分期相关.结论 EGFR、Her-2、VEGF可能参与了子宫颈癌的发生,并在子宫颈癌的发展和转移中起重要作用,可作为评价子宫颈癌恶性程度的指标.

Significance of EGFR,Her-2 and VEGF expressions in cervical intraepithelial neoplasia and squamous cell carcinoma

Objective To investigate the expressions of EGFR,Her-2 and VEGF in cervical intraepithelial neoplasia （CIN） and cervical squamous cell carcinoma,as well as its clinic value of carcinogenesis,progression and metastasis in ccrvical squamous cell carcinoma.Methods EGFR,Her-2 and VEGF were evaluated by immunohistochemistry in tissues from normal cervix,CIN and squamous cell carcinoma.Results The expressions of EGFR,Her-2 and VEGF were negative in normal cervix.The positive rate of EGFR,Her-2 and VEGF in CIN tissues were 35.0 % （14/40）,37.5 % （15/40）,42.5 % （17/40）,while in cervical carcinoma tissues were 70.0 % （35/50）,78.0 % （39/50）,76.0 % （38/50） respectively,which had statistical significance.There was relationship between the expressions of EGFR,Her-2,VEGF proteins with pathological grade andlymph node metastasis of squamous cell carcinoma.The expressions of Her-2 and VEGF correlated with the clinical stage of quamous cell carcinoma.Conclusion The expressions of EGFR,Her-2 and VEGF may be correlated with the occurrence,development and metastasis of cervical carcinoma.It may be used as an important marker to evaluate the malignant degree of cervical carcinoma and it can be helpful in the treatment of cervical carcinoma.