血清中酞酸酯类浓度与肾透析的相关性

[目的]了解肾透析人群体内酞酸酯类的暴露情况。[方法]对某三级甲等医院肾内科透析室就医的52名肾透析病人发放调查问卷，对其肾透析情况进行调查并对回收表进行有效性判断，同时使用气相色谱一质谱联用仪（GC—MS）测定血清样本中酞酸二丁酯（DBP）和酞酸二辛酯（DEHP）水平。[结果]经肾透析管回流入体的静脉血中，52份血样均检出DBP和DEHP，检出率为100％，DBP检出浓度低于DEHP；男、女血清DBP浓度差异无统计学意义，女性DEHP浓度高于男性；每次透析的时长与肾透析病人血清DBP浓度无相关性，但与DEHP的浓度相关；每周不同透析次数病人血清DBP和DEHP的检出浓度差异无统计学意义；每周透析6h的患者共49人，占所有肾透析人数的94．23％；透析年限与肾透析病人血清DBP、DEHP浓度无相关性。[结论]DEHP浓度与肾透析病人的性别、每次透析时长相关；DBP则与病人透析情况无关。

Association of Serum Phthalate Concentrations with Kidney Hemodialysis

[ Objective ] To study phthalate exposure levels in kidney hemodialysis patients. [ Methods ] Dialysis information were collected from 52 patients with kidney hemodialysis treatment in a third-grade-first-class hospital by questionnaires. Concentrations of dibutyl phthalate （DBP） and di-2-ethylhexyl phthalate （DEHP） in serum samples were measured by gas chromatography-mass spectrometry （GC-MS）. [ Results ] Both DBP and DEHP were detected in the serum samples of 52 nephropathy patients （positive rates, 100%）, and the average concentration of DBP was lower than that of DEHP. The DBP concentrations showed no statistical differences between genders, but the average DEHP concentration was higher in female than in male. The single duration of hemodialysis was associated with the DEHP concentrations, but not with the DBP concentrations. No statistical differences in the DBP and the DEHP concentrations were found among patients identified by hemodialysis frequency. Forty-nine patients spent more than 6 h for hemodialysis per week, accounting for 94.23% of total kidney hemodialysis patients interviewed. The hemodialysis years were not associated with either the DBP or the DEHP concentrations in serum. [ Conclusion ] Serum DEHP concentrations in hemodialysis patients are associated with gender and duration of hemodialysis; while DBP concentrations present no association with kidney dialysis.