Plasma cell toll‐like receptor (TLR) expression differs from that of B cells,and plasma cell TLR triggering enhances immunoglobulin production |
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| Authors: | Marcus Dorner Simone Brandt Marianne Tinguely Franziska Zucol Jean‐Pierre Bourquin Ludwig Zauner Christoph Berger Michele Bernasconi Roberto F. Speck David Nadal |
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| Affiliation: | 1. Division of Infectious Diseases and Hospital Epidemiology;2. M.D. and S.B. contributed equally to the work presented in this article.;3. Division of Oncology, Experimental Infectious Diseases and Cancer Research, University Children’s Hospital of Zurich, Zurich;4. Institute of Surgical Pathology, Department of Pathology, University Hospital of Zurich;5. Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland |
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| Abstract: | Toll‐like receptors (TLRs) are key receptors of the innate immune system and show cell subset‐specific expression. We investigated the messenger RNA (mRNA) expression of TLR genes in human haematopoietic stem cells (HSC), in naïve B cells, in memory B cells, in plasma cells from palatine tonsils and in plasma cells from peripheral blood. HSC and plasma cells showed unrestricted expression of TLR1–TLR9, in contrast to B cells which lacked TLR3, TLR4 and TLR8 but expressed mRNA of all other TLRs. We demonstrated, for the first time, that TLR triggering of terminally differentiated plasma cells augments immunoglobulin production. Thus, boosting the immediate antibody response by plasma cells upon pathogen recognition may point to a novel role of TLRs. |
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| Keywords: | B‐cell subpopulations immunoglobulin production mRNA expression plasma cells toll‐like receptors |
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