Modulating T‐cell homeostasis with IL‐7: preclinical and clinical studies |
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| Authors: | C. M. Capitini A. A. Chisti C. L. Mackall |
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| Affiliation: | From the Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA |
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| Abstract: | Interleukin‐7 (IL‐7) is required for the development and survival of T cells and plays a critical role in modulating T‐cell homeostasis. This review will address current understanding of IL‐7 biology, review recent clinical experiences and discuss potential future clinical applications of IL‐7, or IL‐7 blockade, in the setting of disease. |
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| Keywords: | cytokines immunotherapy lymphopenia T cell |
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