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FLUORIMETRIC ASSAY OF CARBOXYLIC ESTER HYDROLASES IN GUINEA-PIG SKIN AND THE EFFECTS OF PROPRANOLOL |
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| Authors: | D. W. K. COTTON,JOSÉ J. M. A. van den,HURK |
| Affiliation: | Department of Dermatology (Professor, W. H. Mali), University of Nijmegen, The Netherlands |
| Abstract: | Summary.— The application of a continuous fluorimetric assay technique to carboxylic ester hydrolases (including the cholinesterases) in skin is described. The kinetic properties of guinea-pig skin preparations from different anatomical sites are reported. The in vitro and in vivo effects of propranolol and some other pharmacological compounds on carboxylic ester hydrolases from guinea-pig skin are described. The results are discussed in relation to atopy. |
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