| 对氧磷酶基因家族 |
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| 引用本文： | 彭薇,张驰,姜晓玲,秦浚川.对氧磷酶基因家族[J].医学分子生物学杂志,2007,4(1):63-66. |
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| 作者姓名： | 彭薇 张驰 姜晓玲 秦浚川 |
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| 作者单位： | 南京大学医药生物技术国家重点实验室,南京市,210093;南京大学医药生物技术国家重点实验室,南京市,210093;南京大学医药生物技术国家重点实验室,南京市,210093;南京大学医药生物技术国家重点实验室,南京市,210093 |
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| 基金项目： | 国家自然科学基金(No.30670858)~~ |
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| 摘 要： | 对氧磷酶(paraoxonases,PONs)是一类广谱的非专一性酯酶。对氧磷酶基因家族有3个成员,包括PON1、PON2和PON3。PON1因水解有机磷毒剂对氧磷而得名,但是,最近的实验表明,PON1有抗氧化作用,能够阻止体内脂质的过氧化。有证据证明,PON1在防治肝损伤及抗动脉粥样硬化方面可能成为基因药物的新靶标。PON2和PON3也有明显的抗氧化性质,体外实验表明PON3比PON1的抗氧化能力更强,因此PON1和PON3基因药物联合应用可能成为防治冠心病的一种新选择。
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| 关 键 词： | 对氧磷酶 酯酶 动脉粥样硬化 基因药物 |
| 修稿时间： | 2006年11月14 |
Paraoxonase Gene Family |
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| PENG Wei,ZHANG Chi,JIANG Xiaoling,QIN Junchuan.Paraoxonase Gene Family[J].Journal of Medical Molecular Biology,2007,4(1):63-66. |
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| Authors: | PENG Wei ZHANG Chi JIANG Xiaoling QIN Junchuan |
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| Abstract: | Paraoxonases are a group of broad-spectrum esterases that catalyze the hydrolysis of many esters and lactones.The paraoxonase gene family consists of 3 members:PON1,PON2 and PON3.PON1 was named after its ability to hydrolyze organophosphate substrate paraoxon.Recent studies revealed that PON1 possesses antioxidant effect,and is capable of preventing lipids from peroxidation in vivo.Evidence suggests that PON1 may act as a new target of gene therapy for liver damage and atherosclerosis.PON2 and PON3 also have obvious antioxidant properties,and in vitro experiments indicated that PON3 has more potent antioxidant effect than PON1.Therefore,combined use of PON1 and PON3 as gene drugs may be a new choice for the treatment of coronary heart disease. |
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| Keywords: | paraoxonase esterase atherosclerosis gene drug |
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