Chai-ling-tang (Japanese name: sairei-to) as an oral adjuvant. |
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Authors: | Y Egawa I Suzuki N Nagi T Yadomae T Kawakita S Kikuchi K Nomoto |
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Institution: | Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy, Japan. |
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Abstract: | Immunomodulating and anti-tumor activities of orally administered Chai-Ling-Tang (Japanese name: sairei-to, ST) were investigated. The oral administration of ST into mice augmented the antibody response to intraperitoneally administered 2, 4, 6-trinitrophenyl-haptenated sheep red blood cells (TNP-SRBC). Orally administered ST showed also an enhancing effect on the antibody response to TNP-SRBC administered by the oral route. In addition, orally administered ST markedly activated the peritoneal macrophages to enhanced phagocytic and lysosomal enzyme activities. A significant inhibition of tumor growth was observed in a syngeneic tumor-mouse system when ST was administered orally. These results suggest that ST has an efficiency as an oral adjuvant or an oral biological response modifier (BRM). |
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