| 细胞外信号调节激酶在直肠癌发生发展中的意义 |
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| 引用本文： | Weirong Chen Ziqun Liao Maogen Chen Gaoyang Cai Tinghan Li. 细胞外信号调节激酶在直肠癌发生发展中的意义[J]. 中德临床肿瘤学杂志, 2008, 7(1): 27-30. DOI: 10.1007/s10330-007-0127-z |
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| 作者姓名： | Weirong Chen Ziqun Liao Maogen Chen Gaoyang Cai Tinghan Li |
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| 作者单位： | Department of General Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China |
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| 基金项目： | Supported by a grant from the Foundation for Medical Scientific Research of Health Bureau of Guangdong Province （No. A2002449）. |
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| 摘 要： | Objective： To study the ERK expression and its significance in the development of human rectal carcinoma. Methods： Samples were obtained from 62 patients with rectal carcinoma, including tumor tissue and adjacent normal rectal tissue. Western blot was used to measure the expression of ERK-1 and ERK-2. S-P immunohistochemical method was used to count the microvessel density （MVD）. Results： ERK-1 and ERK-2 protein levels were increased in rectal carcinoma tissue compared with those in adjacent normal tissues （t = 2.980 and 2.194, P 〈 0.01 and 0.05 respectively）. The MVD was higher in patients with higher ERK-1 and/or ERK-2 protein levels than that in cases with lower ERK-1 and/or ERK-2 levels. Conclusion： Overexpression of ERK-1 and/or ERK-2 may play an important role in the development of human rectal carcinoma, the overexpression can enhance the growth of tumor microvessel and promote the development of human rectal carcinoma.
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| 关 键 词： | rectal carcinoma ERK microvessel density 细胞外信号调节激酶 直肠 癌发生 发展 意义 kinase Significance rectal carcinoma the growth microvessel density promote play role Overexpression cases lower protein levels increased Results |
| 收稿时间： | 2007-06-20 |
| 修稿时间： | 2007-10-07 |
Significance of extracellular signal-regulated kinase (ERK) in the development of rectal carcinoma |
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| Weirong Chen,Ziqun Liao,Maogen Chen,Gaoyang Cai,Tinghan Li. Significance of extracellular signal-regulated kinase (ERK) in the development of rectal carcinoma[J]. The Chinese-German Journal of Clinical Oncology, 2008, 7(1): 27-30. DOI: 10.1007/s10330-007-0127-z |
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| Authors: | Weirong Chen Ziqun Liao Maogen Chen Gaoyang Cai Tinghan Li |
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| Affiliation: | (1) Second Affiliated Hospital of Shantou University Medical College, Shantou, 515041, China |
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| Abstract: | Objective:To study the ERK expression and its significance in the development of human rectal carcinoma.Methods: Samples were obtained from 62 patients with rectal carcinoma, including tumor tissue and adjacent normal rectal tissue. Western blot was used to measure the expression of ERK-1 and ERK-2. S-P immunohistochemical method was used to count the microvessel density (MVD). Results: ERK-1 and ERK-2 protein levels were increased in rectal carcinoma tissue compared with those in adjacent normal tissues (t = 2.980 and 2.194, P ＜ 0.01 and 0.05 respectively). The MVD was higher in patients with higher ERK-1 and/or ERK-2 protein levels than that in cases with lower ERK-1 and/or ERK-2 levels. Conclusion: Overexpression of ERK-1 and/or ERK-2 may play an important role in the development of human rectal carcinoma, the overexpression can enhance the growth of tumor microvessel and promote the development of human rectal carcinoma. |
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| Keywords: | rectal carcinoma ERK microvessel density |
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