Electronic MEMS for triggered delivery |
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Authors: | Richards Grayson Amy C Scheidt Shawgo Rebecca Li Yawen Cima Michael J |
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Institution: | Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 12-011, Cambridge, MA 02139, USA. |
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Abstract: | Implantable electronic devices such as pacemakers and neural implants are often used for electrical stimulation. The usage of microfabrication techniques to produce microelectromechanical systems (MEMS) has allowed engineers to address a wider range of clinical indications. A new direction in the area of MEMS technology is the goal of achieving pulsatile drug delivery. The digital capabilities of MEMS may allow greater temporal control over drug release compared to traditional polymer-based systems, while the batch-processing techniques used in the microelectronics industry can lead to greater device uniformity and reproducibility than is currently available to the pharmaceutical industry. A repertoire of structures, including microreservoirs, micropumps, valves, and sensors, is being developed that will provide a strong foundation for the design of integrated, responsive MEMS for drug delivery. |
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