小儿川崎病血浆D-二聚体测定的临床价值

目的:通过川崎病(KD)患儿D-二聚体的变化研究川崎病血管损伤的机制,并探讨D-二聚体改变与KD合并冠状动脉病变之间的关系。方法:应用酶联免疫吸附实验(ELISA)双抗体夹心法检测35例KD患儿、20例健康对照组儿童的D-二聚体并同时分别测定C反应蛋白(CRP)水平和血小板计数(PLT)。结果:KD患儿组的D-二聚体高于健康对照组,差异有显著性(P<0.01);合并冠状动脉病变(CAL)组D-二聚体明显增高,D-二聚体高于无冠状动脉损伤(NCAL)组,与NCAL组相比有显著差异(P<0.01);CAL组的CRP均呈显著正相关,(r=0.718,P<0.01)。与血小板计数均无相关性。结论:D-二聚体在川崎病血管损伤发生、发展中有着密切的关系。D-二聚体的升高反映了川崎病存在明显的高凝状态和血栓形成倾向。对冠状动脉损伤的并发症具有很大的预测价值。

Exploration for the change of plasma D-dimer in Kawsaki disease

Objective:Through exploring alteration of plasma D-dimer in Kawasaki disease patients to identify direct relationship between plasme D-dimer and Kawasaki disease patients who with coronary artery lesion complication.Method:The levels of plasma D-dimer was measured by enzyme-linked immunosorbent assay and platet count was investigated among 35 KD patients and 20 healthy children.Patients were separated into with coronary artery lesion group and non-coronary artery lesion group.Results:The levels of plasma D-dimer was significantly higher than those in the healthy group(P<0.01).Plasma D-dimer in group CAL keep increasing and was significantly higher than group NCAL(P<0.01).Plasma D-dimer in group CAL has positive correltion with CRP(r=0.718,P<0.01).Conclusion:D-dimer is related to KD.The high levels of D-dimer is related to the severity of vascular damage in KD.It may be a sensitive predictor of coronary artery lesion.