| Chemokines and Chemokine Receptors： Their Manifold Roles in Homeostasis and Disease |
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| 引用本文： | Le Y,Zhou Y,Iribarren P,Wang J. Chemokines and Chemokine Receptors： Their Manifold Roles in Homeostasis and Disease[J]. Cellular & molecular immunology, 2004, 1(2): 95-104 |
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| 作者姓名： | Le Y Zhou Y Iribarren P Wang J |
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| 摘 要： |
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| 关 键 词： | 受体 免疫细胞 靶细胞 炎症反应 |
Chemokines and chemokine receptors: their manifold roles in homeostasis and disease |
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| Le Yingying,Zhou Ye,Iribarren Pablo,Wang Jiming. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease[J]. Cellular & molecular immunology, 2004, 1(2): 95-104 |
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| Authors: | Le Yingying Zhou Ye Iribarren Pablo Wang Jiming |
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| Affiliation: | Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. ley@ncifcrf.gov |
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| Abstract: | Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and injury. In recent years, it has become clear that the function of chemokines extends well beyond the role in leukocyte chemotaxis. They participate in organ development, angiogenesis/angiostasis, leukocyte trafficking and homing, tumorigenesis and metastasis, as well as in immune responses to microbial infection. Therefore, chemokines and their receptors are important targets for modulation of host responses in pathophysiological conditions and for therapeutic intervention of human diseases. |
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