| 脑梗死后抑郁症患者海马及杏仁核体积的MRI研究 |
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| 引用本文： | 陈宇,徐坚民,冯敢生,吴明祥,孙国平,李莹,龚静山,饶梓彬,陈文娇,. 脑梗死后抑郁症患者海马及杏仁核体积的MRI研究[J]. 放射学实践, 2009, 24(6): 603-606 |
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| 作者姓名： | 陈宇 徐坚民 冯敢生 吴明祥 孙国平 李莹 龚静山 饶梓彬 陈文娇 |
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| 作者单位： | 1. 华中科技大学同济医学院附属协和医院,武汉,430022
2. 深圳市人民医院放射科,广东,518020 |
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| 基金项目： | 深圳市卫生局科技重点项目 |
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| 摘 要： | 目的：探讨脑梗死后抑郁症（PSD）患者海马及杏仁核体积改变特点及与抑郁症关系。方法：研究11例梗死后抑郁症（PSD）患者及13例脑梗死无抑郁症（CONT）患者和15例健康志愿（NORM）者,运用容积分析软件测量两侧海马及杏仁核体积。结果：各组均显示海马及杏仁核体积左侧〈右侧,其中PSD组与NORM组两侧海马及杏仁核体积差异有显著性;PSD组中两侧海马及杏仁核体积均明显〈对照组（海马左右P=0.001,0.040;杏仁核左右P=0.000,0.000）,PSD组右侧海马体积明显〈正常组（P=0.034）;PSD患者双侧海马及杏仁核体积缩小与HAMD抑郁量表评分均缺乏相关性。结论：海马及杏仁核体积异常可能构成梗死后抑郁症的神经生物学基础,也说明边缘系统在抑郁症的发病机制中起着重要作用。
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| 关 键 词： | 脑梗死 抑郁症 海马 杏仁核 磁共振成像 |
Volumetric MRI Analysis of the Amygdala and the Hippocampus in Patients with Post-stroke Depression |
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| CHEN Yu,XU Jian-min,FENG Gan-sheng,et al.. Volumetric MRI Analysis of the Amygdala and the Hippocampus in Patients with Post-stroke Depression[J]. Radiologic Practice, 2009, 24(6): 603-606 |
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| Authors: | CHEN Yu XU Jian-min FENG Gan-sheng et al. |
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| Affiliation: | CHEN Yu,XU Jian-min,FENG Gan-sheng,et al.Department of Radiology,Union Hospital,Tongji Medical College,Huazhong Science , Technology University,Wuhan 430022,P.R.China |
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| Abstract: | Objective;To study the MRI volume of the amygdala and hippocampus in patients with post-stroke depression (PSD).Methods:Quantitative MRI of the amygdala and hippocampus was studied in 11 patients with post-stroke depression and compared with 13 stroke patients without depression (CONT) and 15 age-matched controls (NORM).Results:PSD group and NORM group exhisited similar significant hippocampal and amygdala asymmetry (left smaller than right).The volume of the bilateral hippocampus and amygdala was significa... |
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| Keywords: | Brain infarction Depressive disorder Hippocampus Amygdala Magnetic resonance imaging |
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