| FLAG方案再诱导化疗急性髓细胞白血病临床观察 |
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| 引用本文： | 张秀群,张学忠,戴丹,张磊,苏爱玲,胡明秋,苏定雷,徐燕丽.FLAG方案再诱导化疗急性髓细胞白血病临床观察[J].临床血液学杂志,2010(1). |
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| 作者姓名： | 张秀群 张学忠 戴丹 张磊 苏爱玲 胡明秋 苏定雷 徐燕丽 |
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| 作者单位： | 南京医科大学附属南京第一医院血液科; |
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| 摘 要： | 目的:初步探讨氟达拉滨(FDR)、高剂量阿糖胞苷(Ara-C)和粒细胞集落刺激因子(G-CSF)即FLAG方案在急性髓细胞白血病(AML)再诱导化疗中的疗效及不良反应。方法:12例经标准HA、DA、MA或IA方案化疗1疗程后未达完全缓解(CR)、骨髓原始细胞下降低于60%的AML患者,予FLAG方案再诱导化疗,即FDR30mg.m-2.d-1静脉滴注,d1～5;Ara-C1g/m2,静脉滴注,每12h1次,d1～5;G-CSF300μg/d皮下注射,第0天开始至白细胞恢复正常。结果:9例(75%)患者获得CR,3例(25%)患者获得部分缓解(PR)。主要不良反应为骨髓抑制,非血液学不良反应不明显。结论:FLAG方案再诱导化疗AML耐受性较好,有效率较高,不良反应可耐受。
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| 关 键 词： | 白血病 髓细胞性 急性 方案 再诱导 |
The effect of FLAG regimen in the second induction treatment of acute myeloid leukemia |
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| ZHANG Xiuqun ZHAGN Xuezhong DAI Dan ZHANG Lei SU AilingHU Mingqiu SU Dinglei XU Yanli.The effect of FLAG regimen in the second induction treatment of acute myeloid leukemia[J].Journal of Clinical Hematology,2010(1). |
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| Authors: | ZHANG Xiuqun ZHAGN Xuezhong DAI Dan ZHANG Lei SU AilingHU Mingqiu SU Dinglei XU Yanli |
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| Affiliation: | Department of Hematology/a>;Nanjing First Hospital Affiliated to Nanjing Medical University/a>;Nanjing/a>;210006/a>;China |
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| Abstract: | Objective:To observe the therapeutic efficacy and side effects of FLAG regimen fludarabine (FDR),high-dose cytarabine (Ara-C) and granulocyte colony-stimulating factors (G-CSF)] in the second induction treatment of acute myeloid leukemia (AML).Method:Twelve patients with primary AML,who did not achieve complete remission (CR) as blasts in the bone marrow decreased by less than 60% after standardized first-line induction therapies (HA,DA,MA and IA regimen,respectively),were retreated with FLAG regimen,which... |
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| Keywords: | acute myeloid leukemia regimen second induction treatment |
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