肿瘤低剂量CT灌注成像的技术进展

肿瘤的血管生成是其重要特征之一,是肿瘤发生、发展的重要基础,而CT灌注成像(CTPI)作为一种功能成像方法可反映肿瘤内部的血流动力学改变,在临床中常用于鉴别肿瘤性质、肿瘤分期,预测病人疗效、治疗效果等。但CTPI较大的辐射剂量以及在可重复性上存在争议使其发展受到限制。低剂量CTPI能够更好地适应实际临床工作。就低剂量CTPI的原理、技术特点及其在肿瘤成像中的应用前景等予以综述。

Advances of low-dose CT perfusion scanning technique in oncological study

Angiogenesis is an important feature of malignant neoplasm and is the fundamental of genesis and growth of tumors. CT perfusion imaging (CTPI), as one of the functional imaging techniques, can detect neovascularity of neoplasm. It has been applied in a range of clinical areas, such as lesion characterization, staging, predicting patient outcome or response to therapy, assessment of response to different therapies, and so on. However, the major limitations of CTPI are the risk of exposure to ionizing radiation and the dispute of reproducibility of parameters which limit its routine use. Low-dose CT perfusion can be better used in clinical work. In this article we reviewed the basic principles, technique, and various oncological applications of Low-dose CT perfusion.