齐拉西酮与氯氮平对首发精神分裂症患者生活质量影响

目的探讨齐拉西酮治疗对首发精神分裂症患者生活质量的影响。方法以齐拉西酮与氯氮平治疗精神分裂症各40例作对照研究，采用简明精神病评定量表（BPRS）不良反应量表（TESS）评定疗效及不良反应，WHOQOL-BREF量表衡量患者的生活质量。结果最后一次评定，齐拉西酮组BPRS总分降至（15．62±4．37），与治疗前比较有显著性差异（P〈0．01）；氯氮平组BPRS总分降至（16．02±4．63），与治疗前比较有显著性差异（P〈0．01）。两组间疗效无显著性差异（P〉0．05）。氯氮平组毒副作用较齐拉西酮组多。经6个月治疗，齐拉西酮组的身心健康、心理健康、社会关系、环境因素的分值分别为（72．43±4．53），（94．87±10．55），（96．31±12．37），（95．43±10．12），氯氮平组的身心健康、心理健康、社会关系、环境因素的分值分别为（69．81±5．37）、（79．72±11．84）、（80．72±11．42、77）．（74±10．56）。两组患者生活质量较治疗前均有显著改善（P〈0．01），在心理健康、社会关系和环境因素等三方面，齐拉西酮优于氯氮平（P〈0．01）。结论首发精神分裂症患者在提高患者生活质量方面，齐拉西酮优于氯氮平，有利于精神分裂症的远期康复。

Comparative study on the influence of Ziprasidone and clozapine on quality of life in schizophrenic

Objective To investigate the influence on quality of life of Ziprasidone in schizophrenia Methods 40 schizophrenic patients were treated with ziprasidone as the controlled group. The Brief Psychiatric Rating Scale （ BPRS）, while the adverse events were determined by the treatment emergent symptoms scale （TESS）, WHOQOL-BREF instruments were used to evaluate the patients quality of life before and after drug administration. Results For the last assessment ,The scores of BPRS decrease to （ 15.62 ± 4. 37 ） in Ziprasidone group, was significantly lower than the beginning （P 〈0. 01 ） ; the scores of BPRS decrease to（ 16.02 ± 4.63） in clozapine group, was significantly lower than the beginning （ P 〈 0. 01 ） ; Two groups showed similar effects, with no significance. The side effects were more in clozapine group than those in Ziprasidone group. 6 months after treatment, the scores of physical health, psychological health, social relationship, and environment in Ziprasidone group were （ 72.43 ± 4. 53 ）, （ 94. 87 ±10. 55 ）, （ 96. 31 ±12. 37 ）, （ 95.43 ±10. 12 ） ; And the scores of physical halth, psychological health, social relationship, and environment in clozapine group were （69.81±5.37）, （79.72± 11.84）, （80.72 ±11.42）, （77.74± 10.56）. The scores of four domains in WHOQOL-BREF instruments had been improved significantly in two groups （P 〈0.01 ） In the mains of Psychological health, social Relation ship and Environment, Ziprasidone was superior to clozapine （P 〈 0.01 ）. Conclusion Ziprasidone has more advantage than Clozapine to improve quality of life in schizophrenic and would be helpful to patients longterm rehabilitation.