| 龙眼参提取物对耐药口腔上皮样癌细胞株KB／MIT及耐药乳腺癌细胞株MCF-7／ADR的逆转作用 |
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| 引用本文： | 孔晓龙,蒋伟哲,林自中. 龙眼参提取物对耐药口腔上皮样癌细胞株KB／MIT及耐药乳腺癌细胞株MCF-7／ADR的逆转作用[J]. 广西医科大学学报, 2003, 20(4): 495-496 |
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| 作者姓名： | 孔晓龙 蒋伟哲 林自中 |
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| 作者单位： | 广西医科大学第一附属医院药剂科,南宁,530021 |
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| 基金项目： | 广西壮族自治区科技厅基金项目 (桂科攻 0 0 15 0 19) |
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| 摘 要： | 目的：研究龙眼参提取物XCKB／MIT细胞及MCF-7／ADR细胞株的耐药逆转作用。方法：设计4个不同浓度的龙眼参提取物组，采用MTT方法．测定体外培养的阿霉素敏感株MCF-7及其耐药株MCF-7／ADR以及米托蒽醌敏感株KB及其耐药株KB／MIT的IC50。结果：MCF-7／ADR耐药株及KB／MIT耐药株在龙眼参提取物与阿霉素或米托蒽醌的联合用药中其IC50值分别接近于单独用约于敏感株MCF-7和KB的水平．而与单独用药于耐药株其IC50有显著性差异。结论：龙眼参提取物可以逆转MCF7／ADR和KB／MIT的耐药性。
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| 关 键 词： | 龙眼参提取物 耐药性 逆转作用 |
| 修稿时间： | 2003-03-24 |
REVERSAL EFFECT OF EXTRACT FROM LONGYANSHEN ON THE RESISTANCE OF HUMAN CANCER CELLS MCF-7/ADR AND KB/MIT |
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| Kong Xiaolong,Jiang Weizhe,Lin Zizhong.. REVERSAL EFFECT OF EXTRACT FROM LONGYANSHEN ON THE RESISTANCE OF HUMAN CANCER CELLS MCF-7/ADR AND KB/MIT[J]. Journal of Guangxi Medical University, 2003, 20(4): 495-496 |
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| Authors: | Kong Xiaolong Jiang Weizhe Lin Zizhong. |
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| Abstract: | Objective:To study the reversal effect of the extract from longyanshen(EL)on the resistance of human cancer cells MCF 7/ADR and KB/MIT in vitro.Methods:The IC 50 of adriamycin MCF 7 and its resistant line MCF 7/ADR,and IC 50 of mitoxantrone (MIT) on KB and its resistant line KB/MIT were anterminated.Result:IC 50 value of adriamycin or mitoxantrone,in combination on,MCF 7/ADR or KB/MIT was found to be close in the presence of Comgyan shen to that of adriamycin or mitoxantrone alone.On the sensitive cell line MCF 7 or KB,which has singnifieant differences,conpared with the resistant cell line.Conclusion:The drug resistance of MCF 7/ADR or KB/MIT can be reversed by EL. |
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| Keywords: | longyanshen extract drug resistance reversal effect |
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