| 玉泉丸对盐酸二甲双胍大鼠肠吸收的影响 |
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| 引用本文： | 王丹,魏玉辉,段好刚,张帆,张建萍,武新安. 玉泉丸对盐酸二甲双胍大鼠肠吸收的影响[J]. 中国医院药学杂志, 2011, 0(4) |
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| 作者姓名： | 王丹 魏玉辉 段好刚 张帆 张建萍 武新安 |
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| 作者单位： | 兰州大学第一医院药剂科;兰州大学药学院; |
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| 摘 要： | 目的:研究玉泉丸对盐酸二甲双胍大鼠肠吸收的影响。方法:采用大鼠在体肠单向灌流吸收实验模型,应用重量法校正灌流液体积,考察玉泉丸对盐酸二甲双胍肠吸收的影响。结果:盐酸二甲双胍组、盐酸二甲双胍与玉泉丸联合灌流组、玉泉丸诱导组的吸收速率常数分别为0.38,0.28,0.38min-1,吸收渗透系数分别为0.38,0.29,0.37cm.min-1。结论:玉泉丸可能竞争盐酸二甲双胍大鼠肠吸收途径,对盐酸二甲双胍的吸收有一定的抑制作用。
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| 关 键 词： | 盐酸二甲双胍 玉泉丸 单向灌流法 在体肠吸收 |
Effect of Yuquan Pill on absorption of metformin in rat intestine |
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| WANG Dan,,WEI Yu-hui,DUAN Hao-gang,ZHANG Fan,ZHANG Jian-ping,WU Xin-an. Effect of Yuquan Pill on absorption of metformin in rat intestine[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(4) |
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| Authors: | WANG Dan WEI Yu-hui DUAN Hao-gang ZHANG Fan ZHANG Jian-ping WU Xin-an |
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| Affiliation: | WANG Dan1,2,WEI Yu-hui1,DUAN Hao-gang1,ZHANG Fan1,ZHANG Jian-ping1,WU Xin-an1 (1.Department of Pharmacy,The First Hospital of Lanzhou University,Gansu Lanzhou 730000,China,2.College of Pharmaceutical Science,Lanzhou University,China) |
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| Abstract: | OBJECTIVE To evaluate the effect of Yuquan Pill on absorption of metformin by small intestine in rat.METHODS The rat single-pass intestinal perfusion technique was applied,and the gravimetry was used to correct the perfusion volume.The effect of Yuquan Pill on absorption of metformin was studied.RESULTS The absorption rate constant at the metformin group,metformin combined with Yuquan Pill group and Yuquan Pill induced group were 0.38,0.28,0.38 min-1and the apparent intestinal permeability were 0.38,0.29,0.... |
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| Keywords: | metformin Yuquan Pill single-pass intestinal perfusion in vivo intestine absorption |
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