| 蛋白酶体抑制剂治疗多药耐药肿瘤机制的研究进展 |
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| 引用本文： | 刘桐宇,叶建新. 蛋白酶体抑制剂治疗多药耐药肿瘤机制的研究进展[J]. 中华肿瘤防治杂志, 2007, 14(15): 1187-1190 |
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| 作者姓名： | 刘桐宇 叶建新 |
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| 作者单位： | 福建医科大学附属第一医院肿瘤科,福建,福州,350004 |
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| 摘 要： | 多药耐药（multidrug resistance,MDR）是导致肿瘤化疗失败的重要原因,其复杂的机制中涉及许多蛋白的作用,这些蛋白多为蛋白酶体抑制剂的底物。通过蛋白酶体抑制剂可有效逆转MDR现象,它是目前抗癌药物研制领域的一个重要方向。介绍蛋白酶体的作用和MDR,综述近年来关于乳胞素、醛基肽、环孢菌素类似物和硼酸肽这4种蛋白酶体抑制剂对MDR的治疗机制。
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| 关 键 词： | 抗药性,多药 药物耐受性 肿瘤 综述文献 |
| 文章编号： | 1673-5269（2007）15-1187-04 |
| 收稿时间： | 2006-08-01 |
| 修稿时间： | 2006-08-012007-03-10 |
Advance in research on therapeutic mechanism of multidrug resistance of tumor by proteasome inhibitors |
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| LIU tong-yu,YE Jian-xin. Advance in research on therapeutic mechanism of multidrug resistance of tumor by proteasome inhibitors[J]. Chinese Journal of Cancer Prevention and Treatment, 2007, 14(15): 1187-1190 |
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| Authors: | LIU tong-yu YE Jian-xin |
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| Affiliation: | Oncology Department, First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, P.R. China |
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| Abstract: | Multidrug resistance remains a significant impediment to successful chemotherapy associated with complex mechanisms in which several proteins which are substrates of proteasome inhibitors are involved in.Proteasome inhibitors can prevent drug resistance effectively.It is an important direction to the development of anticancer drugs.To introduce MDR and the role of proteasomes,and review the therapeutic mechanism of the treatment for MDR with four representative species of proteasome inhibitors:lactacystin,peptide aldehyde,analog of cyclosporine and peptide boronates. |
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| Keywords: | drug resistance, multiple drug tolerance neoplasm review literature |
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