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VEGF与MMP-2在食管鳞癌中的表达及其临床病理意义
引用本文:陶义鹏,李汉臣,师启重. VEGF与MMP-2在食管鳞癌中的表达及其临床病理意义[J]. 医学信息, 2008, 21(9)
作者姓名:陶义鹏  李汉臣  师启重
作者单位:新乡医学院第一附属医院胸外科,河南卫辉453100
摘    要:目的研究血管内皮生长因子(VEGF)和基质金属蛋白酶-2(MMP-2)在食管鳞癌中的表达与其临床意义。方法用免疫组化染色的方法检测58例食管鳞癌标本及30例取非瘤正常食管组织标本中VEGF与MMP-2蛋白的表达。结果食管鳞癌中VEGF与MMP-2的表达显著高于正常组织,其表达与食管癌的组织侵润深度、淋巴结转移密切相关,两者呈正相关。结论VEGF和MMP-2在食管鳞癌中高表达,参与了食管鳞癌浸润及转移,可以作为判断食管鳞癌生物学行为的指标之一。

关 键 词:食管肿瘤  血管内皮生长因子  基质金属蛋白酶-2

The significance of VEGF and MMP-2 expression in esophage squamous cell carcinoma
TAO Yi-peng,LI Han-chen,SHI Qi-zhong. The significance of VEGF and MMP-2 expression in esophage squamous cell carcinoma[J]. Medical Information, 2008, 21(9)
Authors:TAO Yi-peng  LI Han-chen  SHI Qi-zhong
Affiliation:TAO Yi-peng,LI Han-chen,SHI Qi-zhong(Department of Thoracic,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan Province,China)
Abstract:Objective To investigate the significance of MMP-2 and VEGF expression in esophageal squamous cell carcinoma.Methods The protein expression of MMP-2 and VEGF in 58 cases with esophageal squamous cell carcinoma 30 cases of normal tissue were determined by immunohistochemical streptavidinperoxidase method.Results The expression of MMP-2 and VEGF increase obviously in Escc.The decreased VEGF and MMP-2 expression was correlated with lymph node metastasis infiltration deph and differrntiatiation degree of ESCC,t...
Keywords:esophageal carcinoma  MMP-2  VEGF  immunohistochemistry  
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