血尿酸、颈动脉内中膜厚度与粥样硬化斑块稳定性关系的研究

目的研究冠心病患者血尿酸、颈动脉内膜厚度与粥样硬化斑块稳定性的的关系。方法选择冠状动脉造影确诊的冠心病(CHD)患者81例为实验组,其中血尿酸正常组(Uric≤416 mmol/L)50例,高尿酸血症(Uric>416 mmol L)组31例;冠状动脉造影排除冠心病的患者21例。颈动脉彩超测定颈动脉内中膜厚度,并分析其与斑块稳定性的关系。结果 (1)尿酸与颈动脉内中膜厚度、冠脉Gensin积分呈正直线相关(r=0.506,P<0.05;r=0.321,P<0.05),与高密度脂蛋白呈负相关(r=-0.210,P>0.05),但无直线相关性;(2)高血尿酸组空腹血糖、颈动脉内中膜厚度、冠脉Gensi-ni积分明显高于尿酸正常组,有统计学意义(P<0.05)。结论血尿酸水平与颈动脉内中膜厚度和冠脉Gensini积分有正相关性,与高密度脂蛋白负相关。血尿酸与颈动脉内中膜厚度可以联合预测粥样硬化斑块不稳定性的指标。

The correlates of serum uric acid and the association of uric acid with carotid intimal-medial thickness in elderly patient

Objective To study the correlates of serum uric acid and the association of uric acid with carotid intimal-medial thickness in elderly participants.Methods 81 patients with coronary heart disease(CHD) proved by coronary arterigraphy(CAG) were selected.The carotid IMT was measured by color doppler ultrasonography system.The group of CHD was divided into two groups.Srum uric acid normal group(50 patients) that the level was ≤416 mmol/L.Hyperuricemia group(31 patients) was >416 mmol/L.Results ①Serum uric acid showed positive correlation with carotid intimal-medial thickness and Gensini intergral of coronary artery(r = 0.506,P< 0.05;r =0.321,P< 0.05),and negative correlation with alpha-liporotein(HDL)(r =-0.210,P>0.05),but didn’t have straight line correlation.②Diabetes,fasting blood sugar,carotid intimal-medial thickness and Gensini intergral of coronary artery had significant differences among the two groups(P< 0.05).Conclusion There were significant correlation between serum uric acid and the carotid artery IMT.