101例儿童川崎病临床分析

目的总结川崎病的临床特点。方法分析我院住院确诊的101例川崎病患儿的临床资料。结果川崎病患儿中男79例,女22例,比例为3.59∶1;5岁以下儿童多见,占89.11%;发病全年散发,以3～4月份最多。口唇潮红皲裂是仅次于发热的重要临床表现;卡斑红的临床发生率相对较高。冠状动脉病变发生率为29.70%,心脏损伤不限于冠状动脉,还见于心肌、心内膜和心包;静脉注射丙种球蛋白(IVIG)联合阿司匹林治疗有效率为91.09%。结论早期诊断,及时应用IVIG对川崎病治疗及预防冠状动脉病变有重要意义。

Clinical analysis of 101 Kawasaki disease patients in children

Objective To investigate the clinical features of Kawasaki disease(KD).Methods Clinical data of 101 KD patients in children hospitalized from January 2007 to December 2010 were reviewed.Results A total of 101 cases KD children were enrolled in this study with 79 boys and 22 girls.The ratio of male to female was 3.59 ∶ 1.The children under the age of 5 years accounted for 89.11%.KD occurred all the year and more frequently in March and April.In addition to fever,changes in the oral cavity and lips were the most commonly detected clinical signs in our cases;The clinical incidence of the red card spot was relatitvely higher.Coronary artery abnormalities were detected in thirty patients(29.70%).Not just coronary arteritis,KD were detected myocarditis,endocarditis and valvulitis too.The efficiency of intravenous gamma globulin(IVIG) and aspirin therapy in KD was 91.09%.Conclusion It is very important for KD with early diagnosis and timely application of IVIG for and prevention of coronary artery disease.