Glia maturation factor beta stimulates axon regeneration in transected rat sciatic nerve. |
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| Authors: | K Harman J Katnick R Lim A Zaheer J C de la Torre |
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| Affiliation: | Physiotherapy Program, University of Ottawa, Ont. Canada. |
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| Abstract: | Rat sciatic nerves were bilaterally transected and repaired with an entubulation technique. The nerve interstump gap was filled with either collagen gel or collagen gel mixed with a putative neurotrophic factor (leupeptin, 4-aminopyridine, lipid angiogenic factor or glia maturation factor beta (GMF-beta]. Six weeks after nerve transection, the myelinated distal stump axons were quantified for each nerve. Only the nerves treated with GMF-beta had significantly more axons than the control side. |
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