胰腺实性-假乳头状瘤临床病理特征及免疫表型观察

目的：探讨胰腺实性-假乳头状瘤（SPTP）免疫表型及临床病理特征。方法：对2例SPTP的临床表现、病理学改变、免疫组化等进行分析，并复习相关文献。结果：2例均为女性，且术后无复发。肿瘤有包膜，囊实性相间。瘤细胞围绕纤维血管排列形成假乳头状结构是特征性组织学改变。免疫组化2例肿瘤细胞均阳性的抗体有Vimentin、AAT、CD56、PCNA、MMP9、C-erbB2、Pgp。病例1部分细胞CK7、CD117、β-eatenin阳性，病例2部分细胞Syn、CD10阳性。结论：SPTP是低度恶性肿瘤，多发生在年轻女性，可能来源于多能干细胞。虽然大部分肿瘤呈良性过程，但具有侵袭性行为。免疫组化检测对其组织来源及生物学行为具有提示意义，并可辅助诊断。

Solid-pseudopapillary tumor of the pancreas: a study of clinicopathologic features and immunohistochemistry

Objective： TO explore the clinicopathologic features and the immunohistochemical expression in solid-pseudopapillary tumor of the pancreas （SPTP）. Methods： The clinical manifestations, pathological features and immunohistochemical resuhs in 2 cases of SPTP were analyzed by HE sections, PAS staining and immunohistochemistry （S-P method）. Results： 2 patients with SPTP were both females and had no recurrence after tumor resection. Both tumors were encapsulated and solid alternately with cystic change. Histological features were psudopapillary structure with a fibrovascular core Immunohistochemistry examination showed that Vimentin, AAT, CD56, PCNA, MMP9, C-erbB2, Pgp were all positive in two cases of SPTP. CK7, CD117, β-catenin, Syn, CD10 were positive in one case. Conclusion： SPTP is a tumor with low malignancy of the pancreas that most frequently affect young females. SPTP may derived from muhipotent stem cells. There is a benign clinical course in the most SPTP, but the tumor has a aggressive behavior. Immunohistochemical study could could sugsest, the origin and the biological behavior of SPTP. Immunohistochemistry is important to the diagnosis of SPTP.