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Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma |
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| Authors: | Saji Hisashi Toi Masakazu Saji Shigehira Koike Morio Kohno Kimitoshi Kuwano Michihiko |
| Institution: | a Breast Oncology, Tokyo Metropolitan Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan b Department of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan c Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Japan d Department of Biochemistry, Kyushu University School of Medicine, Fukuoka, Japan |
| Abstract: | Drug resistance is a common clinical problem in cancer treatment. The overexpression of P-glycoprotein appears to be closely associated with multi-drug resistance to anticancer agents. YB-1 binds to the Y-box in the promoter region of MDR1, which encodes P-glycoprotein. We evaluated the correlation between nuclear YB-1 and P-glycoprotein expression and other molecules, such as hormonal receptors, angiogenic factors, immune factors, and methalloprotease in 63 human breast cancers. Nuclear YB-1 expression had a significant correlation with P-glycoprotein and PgR expression, and also with CD68 grade, concerning accumulation of tumor associated macrophages. This series did not demonstrate P-glycoprotein and nuclear YB-1 expression might be one of the useful prognostic marker of breast cancer. |
| Keywords: | YB-1 P-glycoprotein Multi-drug resistance Estrogen receptor PgR Breast carcinoma |
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