| 心力衰竭心阳虚证大鼠与心钠素的相关性研究 |
| |
| 引用本文： | 张友计,雷蕾,李华,杜亮亮,胡节惠.心力衰竭心阳虚证大鼠与心钠素的相关性研究[J].泸州医学院学报,2008,31(5). |
| |
| 作者姓名： | 张友计 雷蕾 李华 杜亮亮 胡节惠 |
| |
| 作者单位： | 泸州医学院附属医院中医科,四川泸州,646000 |
| |
| 摘 要： | 目的:探讨心力衰竭(chronic heart failure,CHF)心阳虚证大鼠心钠素(atrial natriuretic polypeptide,ANP)与心阳气(xin yang qi)之间的相关性及临床意义.方法:以腹腔注射盐酸阿霉素的方法建立大鼠心力衰竭(心阳气虚)模型,另设正常对照组;用放射免疫法测定血浆ANP含量,经颈动脉测量左室收缩压(left ventricular systolic pressure,LVSP)、左室舒张末压(leftventricular end-diastolic pressure,LVEDP)、左室压力最大上升及下降速度(left ventricular developed pressure,±LVdp/dt)心功能指标,测定心肌(左室)匀浆上清液丙二醛(malondialdehyde,MDA)、过氧化物歧化酶(superoxide dismutase,SOD)含量;病理学切片检测,HE染色,显微镜观察;放射免疫法测定心肌(心房)匀浆上清液ANP含量.结果:CHF组大鼠血浆ANP含量显著升高(P<0.01),LVSP、±LVdP/dtmax下降(P<0.01),LVEDP升高(P<0.01),心肌MDA含量升高(P<0.01),心肌SOD活性含量降低(P<0.01),心肌ANP含量升高(P<0.01);CHF时血浆ANP含量与心功能( LVdp/dtmax)(心阳气)呈负相关:r=-0.775(P<0.05).结论:ANP有可能成为评估心力衰竭心阳虚证心阳气水平的指标之一.
|
| 关 键 词： | 心力衰竭 心钠素 心阳气 |
RELATED RESEARCH ON ANP AND XIN YANG XU SYNDROME OF RAT WITH CHRONIC HEART FAILURE |
| |
| Zhang Youji,et al Clinical Institute,Luzhou Medical College.RELATED RESEARCH ON ANP AND XIN YANG XU SYNDROME OF RAT WITH CHRONIC HEART FAILURE[J].Journal of Luzhou Medical College,2008,31(5). |
| |
| Authors: | Zhang Youji Clinical Institute Luzhou Medical College |
| |
| Abstract: | Objective: To investigate the relationship between atrial natriuretic polypeptide (ANP) and xin yang qi(positive vital energy of heart) of rat with chronic heart failure.Methods: Chronic heart failure(xin yang qi xu) model of rats by the method of intraperitoneal injection of doxorubicin hydrochloride (ADR),and control group was set up.Plasma ANP was determined by radioimmunoassay (RIA); left ventricular systolic blood pressure(LVSP),left ventricular end-diastolic pressure (LVEDP),and the maximum increased ... |
| |
| Keywords: | Chronic heart failure (CHF) Atrial natriuretic peptide (ANP) Xin yang qi |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
