不同程度妊娠肝内胆汁淤积症与围产儿预后的关系

目的　探讨妊娠肝内胆汁淤积症 (intrahepaticcholestasisofpregnancy ,ICP)患者胆汁酸、转氨酶和胆红素变化与围产儿预后的关系。　方法　将 116例妊娠肝内胆汁淤积症患者根据血清总胆汁酸、谷丙转氨酶及总胆红素的变化分为轻、中、重 3组 ,对其分娩方式、围产儿结局进行比较。　结果　羊水污染发生率、新生儿窒息率、剖宫产率各组均有显著性差异 (P <0 .0 5或P <0 .0 1)。　结论　妊娠肝内胆汁淤积症患者胆汁酸愈高 ,肝功能损害愈重剖宫产率愈高 ,围产儿预后愈差。

THE Perinatal Prognosis in Patients with Different Degrees of Intrahepatic Cholestasis in Pregnancy

Objective To investigate the relationships between perinatal prognosis and the levels of bile acids, alanine aminotransferase and total bilirubin in patients with intrahepatic cholestasis of pregnancy (ICP). Methods 116 cases of ICP were divided into three groups as mild, moderate and severe ICP according to the serum levels of bile acids, alanine aminotransferase and total bilirubin in the patients. The mode of delivery and outcome were compared. Results the The incidence of amnion fluid, neonatal asphyxia and caesarean section rate were significantly different between groups (P<(0.05), or P<0.01 ). Conclusion the level of bile acids and the degree of liver damage are important factors in predicting the perinatal prognosis.