子宫内膜异位症患者GnRH-a预治疗后不同启动时间体外受精效果分析

目的探讨子宫内膜异位症（EMs）患者促性腺激素释放激素激动剂（GnRH-a）预治疗后的有效促排卵方案。方法收集EMs患者接受体外受精-胚胎移植（IVF-ET）治疗的35例,于GnRH-a预治疗后月经周期第3天启动（A组）与GnRH-a预治疗后第28天启动组（B组）的两个不同时期予以促性腺激素（Gn）超促排卵,并与单纯性输卵管因素不孕患者80例（C组）治疗结局作比较。结果 3组年龄、不孕年限、种植率和临床妊娠率差异均无统计学意义（均P〉0.05）。3组Gn使用天数、注射人绒毛膜促性腺激素（hCG）日E2水平差异有统计学意义（P〈0.05）,获卵数、受精数、卵裂数和移植胚胎数差异均无统计学意义（均P〉0.05）。讨论GnRH-a预治疗EMs患者后,于月经周期第3天启动超排卵的方案,值得在临床中试用。

Outcome of different GnRH agonist down-regulation regimens during in vitro fertilization-embryo transfer on endometriosis patients

Objective To investigate the suitable protocol after GnRH agonist down-regulation treatment during in vitro fertilization-embryo（IVF-ET）on endometriosis patients associated with infertility.Methods 35 patients receiv-ed IVF-ET were included in this study A.After 3 month,15 patients were in group A,who were received Gn treatment on the third day of menstrual cycle;20 patients were in group B,who were received Gn treatment on the 28th day after the last injection day.80 infertility patients with tubar factor were in the control group（group C）.Results There were no significant difference among the three groups on age,infertility time,implantation rate and gestation rate（P〉0.05）.There were significant differences among three groups on treatment time of Gn and E2 level on the injection day（P〉0.05）.There were no significant differences among three groups on the number of ovum,fertilized ovum and im-planted embryo（P〉0.05）.Conclusions Controled ovarian hyperstimulation on the third day of menstrual is advised after GnRH agonist down-regualtion of emdometriosis patients.