Circulatory parameters in the retrobulbar central retinal artery and vein of patients with diabetes and medically treated systemic hypertension |
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Authors: | Galina Dimitrova Satoshi Kato Harumi Fukushima Hidetoshi Yamashita |
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Institution: | (1) Center for Eye Diseases “OKO”, Dame Gruev 5, Skopje, Republic of Macedonia;(2) Department of Ophthalmology, Tokyo University Hospital, Tokyo, Japan;(3) Department of Ophthalmology, Medical Faculty, Yamagata University, Yamagata, Japan |
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Abstract: | Background We aim to study the circulatory parameters in the retrobulbar central retinal artery and vein in diabetic patients with and
without medically treated systemic hypertension.
Methods The study included 108 patients with diabetes that were allocated in four different groups according to the presence of diabetic
retinopathy (DR) and hypertension: group 1—patients without DR and without hypertension (n = 23), group 2—patients without DR and with hypertension (n = 21), group 3—patients with nonproliferative DR and without hypertension (n = 36), group 4—patients with nonproliferative DR and with hypertension (n = 28). The circulatory parameters that were evaluated were: peak systolic blood velocity (PSV), end-diastolic blood velocity
(EDV), maximum venous velocity (Vmax), minimum venous velocity (Vmin) and the Pourcelot index which were measured using color
Doppler imaging. Non-parametric tests were used to test inter-group differences. Spearman’s coefficient of correlation was
tested between ocular perfusion pressure and the circulatory parameters in each of the patient groups. Contingency table was
performed to test the relation of diabetic retinopathy and hypertension to the PSV in the central retinal artery.
Results The PSV and EDV in the central retinal artery was significantly higher in group 1 (p = 0.02, p = 0.04) and group 2 (p = 0.02, p = 0.02) than in group 3. The Pourcelot index in the central retinal vein was significantly lower in group 1 than in group
4 (p = 0.02), and in group 2 than in groups 3 and 4 (p = 0.02, p < 0.01). A significant relationship was detected between the presence of hypertension, the stage of diabetic retinopathy
and the PSV in the central retinal artery of our patients (χ2 = 8.29; p = 0.04).
Conclusion Medically treated hypertension affects the retrobulbar circulatory parameters in the central retinal artery and vein in diabetes. |
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Keywords: | Diabetic retinopathy Hypertension Anti-hypertensive therapy Retrobulbar blood circulation Color Doppler imaging |
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