Minichromosome maintenance 2 expression is correlated with mode of invasion and prognosis in oral squamous cell carcinomas |
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Authors: | Isamu Kodani Mitsuhiko Osaki Kohei Shomori Kunio Araki Eizo Goto Kazuo Ryoke Hisao Ito |
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Institution: | First Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan. ikodani@grape.med.tottori-u.ac.jp |
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Abstract: | BACKGROUND: This study examined the immunohistochemical expression of cell-cycle related molecules as well as cell proliferation and pathologic findings in oral squamous cell carcinoma (SCC) in order to clarify their pathobiologic and prognostic significance. METHODS: A total of 46 oral SCC specimens were analyzed using Ki-67, minichromosome maintenance 2 (MCM2), p53, p27, p21, and TUNEL. Aspects including tumor differentiation, mode of carcinoma invasion, tumor metastasis, and patient prognosis were compared among the specimens. RESULTS: A significantly higher MCM2 labeling index (LI) was observed in the moderately differentiated SCCs when compared to the well-differentiated SCCs (P<0.05). The higher MCM2 LI was correlated with mode of invasion Grade 4 (infiltrative growth) and patient prognosis. In contrast, the LIs of Ki-67, TUNEL-signal, p53, p27, and p21 were not correlated with patient prognosis. CONCLUSION: Higher MCM2 LI provides useful information for patient prognosis in oral SCCs. |
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Keywords: | apoptosis differentiation minichromosome maintenance 2 (MCM2) mode of carcinoma invasion |
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