香菇菌多糖联合5%咪喹莫特乳膏预防尖锐湿疣CO_2激光术后复发的疗效观察

目的观察CO2激光去除疣体后,联合应用全身及局部免疫调节剂香菇菌多糖和5%咪喹莫特乳膏预防尖锐湿疣复发的疗效。方法将患者按就诊先后随机分为三组,先用CO2激光去除疣体后:A组给予口服香菇菌多糖片10mg,3次/d;待创面愈合后,同时给予5%咪喹莫特乳膏外用,每周二、四、六晚涂药3次。B组单纯给予5%咪喹莫特乳膏外用。C组单纯给予口服香菇菌多糖片。用法及用量同A组。3组疗程均为8周。观察复发情况及不良反应,12周后进行复发率比较。结果 2周后A,B,C3组的复发率分别为10.42%,30.00%,33.33%。A组复发率明显低于B,C组,差异有统计学意义(P均<0.05)。结论联合应用免疫调节剂香菇菌多糖和5%咪喹莫特乳膏预防尖锐湿疣复发疗效好,复发率低。

Observation on Recurrence of Condyloma Acuminatum with Lentinus Edodes Mycelia Polysacharide Combined with 5% Imiquimod Cream Threapy after Carbon Dioxido Laser Surgery

Objective To observe the efficacy of lentinus edodes mycelia polysacharide combined with 5% imiquimod cream in preventing the recurrence of condyloma acuminatum after CO2 laser surgery. Methods All the patients were treated with CO2 laser firstly and then were divided into A,B,C three groups randomly.The group A was treated with lentinus edodes mycelia polysacharide 10mg,tid,and 5% imiquimod cream 3 times a week.The group B was only treated with 5% imiquimod cream.The group C was only treated with lentinus edodes mycelia polysacharide.The course of three groups was for 8 weeks.The recurrence of the situation was carried out after 12 weeks.Results After 12 weeks,The recurrence rates of three groups were 10.42%,30.00%,33.33% respectively.The recurrence rates of the group B and C were significantly higher than that in the group A. Conclusions Lentinus edodes mycelia polysacharide combined with 5% imiquimod in the treatment of condyloma acuminatum have a more satisfactory effect,and significantly reduce relapse.