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| 胃癌组织中CD133蛋白表达及其临床意义 | |
| 引用本文： | 张鹏,吴巨钢,俞继卫,倪晓春,伍宏彪,李小强,姜波健.胃癌组织中CD133蛋白表达及其临床意义[J].中国普外基础与临床杂志,2011,18(3):281-285. |
| 作者姓名： | 张鹏 吴巨钢 俞继卫 倪晓春 伍宏彪 李小强 姜波健 |
| 作者单位： | 1. 河南省人民医院普外科工作,河南,郑州,450003 2. 上海交通大学医学院附属第三人民医院普外科,上海,201900 3. 上海交通大学医学院附属第三人民医院病理科,上海,201900 |
| 基金项目： | 上海交通大学医学院科研项目赞助，上海市科委科研项目赞助 |
| 摘 要： | 目的研究胃腺癌组织中CD133蛋白表达及其临床意义。方法应用免疫组织化学染色方法检测99例胃癌患者手术切除的原发灶及正常胃黏膜组织中CD133蛋白的表达,分析其与临床病理特征和预后的关系。结果 29例(29.29%)患者肿瘤组织中CD133蛋白表达阳性,正常胃黏膜组织中均为阴性(P=0.000)。肿瘤直径>5 cm者CD133蛋白表达阳性率显著高于≤5 cm者(P=0.041);CD133蛋白表达与TNM分期有关(P=0.044);有淋巴结转移(P=0.017)、淋巴管浸润(P=0.000)和血管浸润(P=0.000)者,CD133蛋白表达显著增高。logistic回归分析显示:肿瘤浸润深度(P=0.011)、淋巴结转移(P=0.043)和TNM分期(P=0.049)分别是CD133蛋白表达阳性的独立危险因素。CD133蛋白表达阳性患者的术后生存时间短于表达阴性患者(P=0.046)。Cox比例风险回归模型分析显示,有淋巴结转移(P=0.042)、TNM分期(P=0.046)及CD133蛋白表达阳性(P=0.046)分别是胃癌患者预后的独立危险因素。结论胃癌组织中CD133蛋白的表达与胃癌的发展、转移及预后密切相关。 |
| 关 键 词： | 胃癌 CD133蛋白 淋巴结转移 临床病理特征 预后 |
Expression of CD133 Protein in Primary Lesions of Gastric Cancer and Its Clinical Significance |
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| ZHANG Peng,WU Ju-gang,YU Ji-wei,NI Xiao-chun,WU Hong-biao,Li Xiao-qiang,JIANG Bo-jian.Expression of CD133 Protein in Primary Lesions of Gastric Cancer and Its Clinical Significance[J].Chinese Journal of Bases and Clinics In General Surgery,2011,18(3):281-285. | |
| Authors: | ZHANG Peng WU Ju-gang YU Ji-wei NI Xiao-chun WU Hong-biao Li Xiao-qiang JIANG Bo-jian |
| Institution: | ZHANG Peng1,WU Ju-gang1,YU Ji-wei1,NI Xiao-chun1,WU Hong-biao1,LI Xiao-qiang2,JIANG Bo-jian1.1.Department of General Surgery,The Third People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201900,China,2.Department of Pathology |
| Abstract: | Objective To investigate the expression of CD133 protein in primary lesions of gastric cancer and its clinical significance.Methods The expressions of CD133 protein in the primary lesion of tumor and normal gastric mucosa tissues confirmed by using histopathologic examination of 99 patients were detected by immunohistochemical staining.The correlation of CD133 protein expression with the clinicopathologic parameters and features after operation were analyzed.Results Positive cells of CD133 protein were loca... |
| Keywords: | Gastric cancer CD133 protein Lymph node metastasis Clinicopathologic feature Prognosis |
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